Human IL-28A/IFN Lambda 2, HCE

Product Features:

Recombinant Human Interleukin-28A/IFN Lambda 2 expressed in human cells

Full Product Name: Human Interleukin-28A (IL-28A)/Interferon Lambda 2, Human Cell-Expressed (HCE)

Catalog No.	Pack Size	Price	Quantity
11720-1	≥ 1 x 10⁵ units	$270.00

Specifications
Tech Info / Data
Citations
Documentation

Specifications

Formulation	Supplied frozen in phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Molecular Weight	19.8 kDa
Source	Recombinant DNA expressed in human cells
Purity	Greater than 95% as determined by ion exchange, hydrophobic interaction and/or size exclusion chromatographyEndotoxin level < 1 EU/μg
Bioactivity	Measured in cytopathic effect inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV), EC₅₀ ~1 U/ml
Storage	For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms	Hu-IL-28A; Hu-IFN-λ2
Accession Number	NP_742150.1

Tech Info / Data

Background:

Interferon lambda 1 (IL-29), interferon lambda 2 (IL-28A) and interferon lambda 3 (IL-28B) are recently identified members of the IL-10 family which have antiviral activity similar to type I interferons. They mediate this activity through a heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λ R1). Engagement of this receptor leads to Jak-STAT signaling and gene expression. Many of the effects of interferon lambda on cells overlap that of Type I interferon. Unlike the type interferon receptor which is found on virtually all cells, the type III receptor is limited in its expression. Interferon lambda 1 encodes a 181 amino acid mature protein which is 67% and 69% identical with interferon lambda 2 and interferon lambda 3, respectively.